Lambert-Eaton Myasthenic Syndrome

Lambert-Eaton myasthenic syndrome is a rare autoimmune disorder of the neuromuscular junction. It is frequently associated with malignancy, particularly small cell lung cancer. The main symptoms include gradually progressive muscle weakness, fatigability, and dry mouth. Physical examination commonly reveals proximal muscle weakness, particularly of the thigh muscles, diminished or absent deep tendon reflexes, and dilated pupils with reduced light reactivity. Approximately 40% of individuals with Lambert-Eaton myasthenic syndrome have small cell lung cancer. Effective treatment of the underlying malignancy often leads to improvement of neurological symptoms.

Source | Author Doctor Nikas Samuolis, reviewed by Prof. Virginijus Šapoka | Vilnius University | Faculty of Medicine | Head of the Department of Internal Medicine, Family Medicine, and Oncology