Salicylate Poisoning

Description of the Condition

Salicylate poisoning occurs after excessive exposure to salicylates, most commonly aspirin (acetylsalicylic acid), or other substances that are metabolized into salicylates. Poisoning may be acute, resulting from a single large ingestion, or chronic, developing after prolonged use of high doses.

Salicylate poisoning can cause serious disturbances in acid-base balance, electrolyte levels, and central nervous system function. Acute poisoning typically occurs after ingestion of more than 150 mg/kg of aspirin (or approximately 6.5 g in adults). Chronic poisoning may develop with prolonged intake of approximately 150 mg/kg per day.

Some products, including certain antifreeze solutions and other industrial chemicals, may contain salicylates or salicylate derivatives. Poisoning may occur after ingestion of relatively small amounts of these substances, depending on their concentration and formulation.

Source | Author Doctor Nikas Samuolis, reviewed by Prof. Virginijus Šapoka | Vilnius University | Faculty of Medicine | Head of the Department of Internal Medicine, Family Medicine, and Oncology